Tau pathology and cognitive reserve in Alzheimer’s disease


Cognitive reserve (CR) is defined as the ability to maintain functionality despite accumulating pathology and education has been used as a proxy for CR. For example, by using PET imaging higher educated Alzheimer’s disease (AD) patients presented increased beta amyloid pathology than lower educated patients despite equal symptomatology. Whether similar associations exist for in vivo tau pathology remains elusive. We utilized [18F]AV-1451 PET imaging to examine whether high educated AD patients (n=12) present more severe tau pathology compared to low educated patients (n=12) despite equal clinical severity in regions of interest corresponding to the pathological disease stages defined by Braak & Braak.📍

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