Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation


The brain mechanisms underlying the effect of education may evolve along the normal aging-Alzheimer’s disease (AD) cognitive spectrum and may include both protective and compensatory mechanisms. We assessed the association between education (years) and average cortical Florbetapir SUVR as well as performed voxel-wise analyses in a total of 140 participants, including cognitively normal older adults, mild cognitive impairment (MCI) and AD patients. Higher education was associated with lower cortical Florbetapir-PET uptake, notably in the frontal lobe in normal older adults, but with higher uptake in frontal, temporal and parietal regions in MCI.📍

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