Presenilin 1 mutation decreases both calcium and contractile responses in cerebral arteries

Mutation or upregulation in Presenilin 1 (PS1) gene are found in familial early-onset Alzheimer’s disease (AD) or sporadic late-onset AD, respectively. PS1 has been essentially studied in neurons and its mutation was shown to alter intracellular calcium (Ca2+) signals. Here, we showed that PS1 is expressed in smooth muscle cells (SMC) of mouse cerebral arteries, and we assessed the effects of the deletion of exon 9 of PS1 (PS1dE9) on Ca2+ signals and contractile responses of vascular SMC. Agonist-induced contraction of cerebral vessels was significantly decreased in PS1dE9 both in-vivo and ex-vivo.📍


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