Evaluating Alzheimer Disease Biomarkers as Mediators of Age-Related Cognitive Decline


Age-related changes in cognition are partially mediated by the presence of neuropathology and neurodegeneration. This manuscript evaluates the degree to which biomarkers of Alzheimer’s disease (AD) neuropathology and longitudinal changes in brain structure account for age-related differences in cognition. Data from the AD Neuroimaging Initiative (n=1012) were analyzed, including individuals with normal cognition and mild cognitive impairment. Parallel process mixed effects regression models characterized longitudinal trajectories of cognitive variables and time varying changes in brain volumes.📍

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