CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients

A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined CSF/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer’s disease (AD, early onset [EAD, n=130], late onset AD [LAD, n=666]), vascular dementia (VaD, n=255), mixed AD and VaD (MIX, n=362), Lewy body dementia (DLB, n=50), frontotemporal dementia (FTD, n=56), Parkinson’s disease dementia (PDD, n=23), other dementias (Other, n=48) and dementia not otherwise specified (NOS, n=271).📍


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