TMEM106B and ApoE polymorphisms in CHMP2B mediated frontotemporal dementia (FTD-3)


Single-nucleotide polymorphisms (SNPs) in the TMEM106B gene have been identified as a risk factor in frontotemporal dementia (FTD). The major allele of SNP rs3173615 is a risk factor in sporadic FTD, while the minor allele seems protective in GRN- and C9orf72-mediated FTD. The role of Apolipoprotein E (ApoE) in FTD is uncertain, though an established risk factor in Alzheimer’s disease.In a unique Danish family, inherited FTD is caused by a mutation in the CHMP2B gene located on chromosome 3 (FTD-3).📍

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