Transthyretin neuroprotection in Alzheimer’s disease is dependent on proteolysis


The deposition of amyloid β peptide (Aβ) in the hippocampus is one of the major hallmarks of Alzheimer’s disease, a neurodegenerative disorder characterized by memory loss and cognitive impairment. The modulation of Aβ levels in the brain results from an equilibrium between its production from the amyloid precursor protein (APP) and removal by amyloid clearance proteins, which might occur via enzymatic (Aβ-degrading enzymes) or non-enzymatic (binding/transport proteins) reactions. Transthyretin (TTR) is one of the major Aβ binding proteins acting as a neuroprotector in AD.📍

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