Incident Risk and Progression of Cerebral Microbleeds in Healthy Adults: A Multi-Occasion Longitudinal Study


Decline in cerebrovascular health complicates brain aging and development of cerebral microbleeds (CMBs) is one of its prominent indicators. In a large sample of healthy adults (N = 251, age 18-78 years at baseline, 70% women), the contributions of chronological age and vascular health indicators to risk of developing a CMB was examined in a prospective eight-year longitudinal study, as well as change in CMB size and iron content from susceptibility weighted imaging. Twenty-six persons (10.4%), most of whom were 40 years of age or older, had at least one CMB during the study.📍

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