Antibody recognizing 4-sulphated chondroitin sulphate proteoglycans restores memory in tauopathy-induced neurodegeneration.


Chondroitin sulphate proteoglycans (CSPGs) are the main active component of perineuronal nets (PNNs). Digestion of the glycosaminoglycan chains of CSPGs with chondroitinase ABC or transgenic attenuation of PNNs leads to prolongation of object recognition memory and activation of various forms of plasticity in the adult CNS. The inhibitory properties of the CSPGs depend on the pattern of sulphation of their glycosaminoglycans, with chondroitin 4-sulphate (C4S) being the most inhibitory form. In this study we tested a number of candidates for functional blocking of C4S, leading to selection of an antibody, Cat316, which specifically recognises C4S and blocks its inhibitory effects on axon growth.📍

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